7-Hydroxymitragynine (7-OH) is a potent mu-opioid agonist found in kratom, typically taken in tablet or extract form. Understanding dosage thresholds and managing tolerance is critical to safe use.
⚠️ Warning: These dosage ranges are based on anecdotal reports and may vary widely by user tolerance. Start low.
🟢 Light: 5–10 mg — calm mood lift, minor euphoria, subtle analgesia🟡 Moderate: 15–25 mg — moderate warmth, relaxation, physical sedation🔴 Strong: 30–40 mg — heavy body load, strong euphoria, likely nodding🚫 High Risk: 50 mg+ — excessive sedation, nausea risk, high tolerance only
Oral onset: 15–45 minutes
Peak: ~90 minutes
Duration: ~3–4 hours
Tolerance begins developing with daily use in as little as 3–5 days
Frequent users report needing 2–3× their original dose within weeks
Cross-tolerance with other opioids is well-documented
Example: A new user may feel strong effects at 20 mg, but require 35–40 mg after two weeks of continuous use.
2–3 day break: minimal effect7–14 day break: partial reset in most users21+ day break: near full sensitivity recoveryUse cycles like 3 days on / 4 days off to manage long-term
Stick to the lowest effective dose (LED)
Never combine with other depressants (alcohol, benzos, opioids)
Track usage using a log or tracker app
Use extract or tablet form for consistent mg dosing
Rotate with non-opioid nootropics if needed
Kruegel AC et al. (2016) – Biased Mu-Opioid Agonist Study
US FDA Kratom Alkaloid Reports (2021–2023)
User-reported dosing logs from Reddit, Erowid, Bluelight
© 2025 Alkaloid Boys — All content is informational only.