¶ Pharmacological Profile of 7-Hydroxymitragynine (7-OH)
7-OH Mitragynine is a potent alkaloid derived from the kratom plant (Mitragyna speciosa), and is primarily responsible for the plant’s opioid-like effects.
Acts as a G-protein biased MOR agonist, which may explain its reduced side effect profile (e.g., less constipation, nausea, and respiratory suppression compared to full opioids).