⚠️ Disclaimer: This page is for educational purposes only and does not replace medical advice. Always consult a healthcare provider if you are considering tapering or discontinuing use of any opioid-like substance.
7-Hydroxymitragynine (7-OH) is a potent mu-opioid receptor agonist found in kratom and kratom-derived extracts. Although natural, 7-OH shares key pharmacological similarities with conventional opioids — and therefore carries a risk of dependence, withdrawal, and tolerance escalation.
Although typically milder than full-synthetic opioids, 7-OH withdrawal can be physically and mentally distressing. Reported symptoms include:
Restless legs
Muscle aches and chills
Fatigue and brain fog
Runny nose, sweating
Depression and irritability
Diarrhea and gastrointestinal discomfort
Cravings, rebound anxiety
Symptoms usually begin 12–24 hours after last dose and may peak around days 2–3. Acute symptoms typically resolve in 4–7 days, but mental effects (anhedonia, insomnia) can linger for weeks.
Benzodiazepines can help manage anxiety, insomnia, and muscle tension during acute 7-OH withdrawal, but come with high risk if misused:
Short-term only: Limit use to 3–5 days max
Safe options: Diazepam, clonazepam, lorazepam (only at low doses)
Do not combine with 7-OH or other opioids — may cause fatal respiratory depression
Prefer alternatives like hydroxyzine, gabapentin, or kanna when possible
Benzos are effective for short-term relief, but trading one dependency for another can derail recovery. Only use under supervision if absolutely necessary.
Mental symptoms can persist even after physical withdrawal ends:
Anhedonia (lack of pleasure)
Low motivation and energy
Mild panic or intrusive thoughts
It is important to engage in mood-boosting, low-pressure activities (walking, music, journaling), avoid social isolation, and give the brain time to stabilize its endogenous opioid system.